Cannabinoids, the active compounds in cannabis, have been extensively studied for their potential in managing chronic pain. Recent research provides insights into their efficacy and safety: Comparative Effectiveness with Opioids A systematic review and 8 products network meta-analysis evaluated the benefits and harms of medical cannabis versus opioids for chronic non-cancer pain. The study found that both cannabinoids and opioids offer small improvements in pain relief, physical functioning, and sleep quality compared to placebo.

Notably, cannabis resulted in fewer discontinuations due to adverse events than opioids, suggesting a more favorable safety profile. BMJ OPEN Clinical Practice Guidelines The BMJ issued a clinical practice guideline recommending a trial of non-inhaled medical cannabis or cannabinoids for individuals with chronic pain unresponsive to standard care. This recommendation is based on moderate to high certainty evidence indicating small improvements in pain relief, sleep quality, and physical functioning.

BMJ Long-Term Safety Considerations While short-term use of cannabinoids appears to be relatively safe, concerns remain regarding long-term and serious harms. A systematic review highlighted the need for more research to establish the prevalence of such adverse effects in chronic pain management. BMJ OPEN Conclusion Current evidence suggests that cannabinoids may offer modest benefits in managing chronic pain, with a potentially better safety profile compared to opioids.

However, further research is necessary to fully understand their long-term efficacy and safety. Patients should consult healthcare professionals to determine the appropriateness of cannabinoid-based therapies for their specific conditions.